Peer-reviewed veterinary case report
The Effect of Stromal-Derived Factor 1on Osteoinduction Properties of Porous-Tricalcium Phosphate Bioceramics.
- Journal:
- BioMed research international
- Year:
- 2021
- Authors:
- Jin, Fangchun et al.
- Affiliation:
- Department of Pediatric Orthopaedics · China
- Species:
- rabbit
Abstract
-Tricalcium phosphate (TCP) is a type of bioceramic material which is commonly used for hard tissue repair and famous of its remarkable biocompatibility and osteoconductivity with similar composition to natural bone. However, TCP lacks osteoindcutive properties. Stromal-derived factor 1(SDF-1) can promote bone regeneration with excellent osteoinduction effect. In this study, SDF-1was loaded into TCP to investigate theeffects of SDF-1on the osteoinductive properties of TCP.studies showed that SDF-1/TCP scaffold significantly stimulated the expression of osteopontin and osteocalcin. As to thestudies, the rabbit bone defect model showed that SDF-1stimulated more new bone formation. In conclusion, SDF-1/TCP bioceramic scaffolds could further promote bone regeneration compared to pure TCP bioceramics.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34046501/