The effect of coffee consumption on liver function in adult male rabbits

Abstract

This study was carried out on 10 adult male Rabbits to investigate  the effect of Coffee at a dose  ( 100 mg/ Kg B.W. / day) orally on the liver function by measuring the Liver enzymes such as [Glutamic Oxaloacetate transaminase (GOT) , Glutamic Pyruvic Transminase (GPT) , Total serum Billirubin  (TSB) and Alkaline phosphatase (ALP)].  This study was lasted for one month and blood samples was taken at the end of the 2nd week and 4th week for determination the biochemical parameters.(GOT/GPT/ALP/TSB)     The results showed that a significant increasing (P < 0.05) in the level of GPT, GOT and ALP enzymes in2nd&4th weeks in treated group as compared with the Control group with no significant increasing  (P < 0.05) in the TSB level in treated group as compared with the Control group.     That indicate the stimulatory effect of Coffee on liver functions. Key word: Coffee, Caffeine, GPT, GOT , TSB ,. ALP.