Peer-reviewed veterinary case report
The effect of aspirin and high fibre diet on colorectal carcinoma: a comparative experimental study.
- Journal:
- Techniques in coloproctology
- Year:
- 2004
- Authors:
- Miliaras, S et al.
- Affiliation:
- 1st Surgical Department
- Species:
- rodent
Abstract
BACKGROUND: The aim of this study is to assess the role of high fibre diet and aspirin on dimethylhydrazine (DMH)-induced colorectal cancer in rats. MATERIALS AND METHODS: Colorectal tumours were induced with DMH. The animals were randomly divided into five groups (15 rats each): I, controls; II, rats receiving only the carcinogen; III, rats receiving the carcinogen and high fibre diet; IVA, rats receiving the carcinogen plus low dose aspirin; IVB, rats receiving the carcinogen plus high dose aspirin. RESULTS: Adenocarcinomas were detected in 100% of the rats in group II, 47% of the rats in group III (chi2, p<0.05), 100% of the rats in group IVA, but the incidence was reduced to 50% in the rats of group IVB (p<0.05). CONCLUSIONS: These data indicate that high fibre diet and aspirin suppress experimental colon carcinogenesis and the protective effect of aspirin is dose related.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15655645/