Peer-reviewed veterinary case report
The effect of apricots on the experimental cataract model formed by sodium selenite.
- Journal:
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Year:
- 2013
- Authors:
- Doganay, Selim et al.
- Affiliation:
- Inonu University School of Medicine
- Species:
- rodent
Abstract
This study was designed in order to investigate whether sun dried apricots have a preventive effect on the experimental cataract model formed by sodium selenite in rats. Fifty-nine Spraque-Dawley rat pups were divided into three groups. Group 1 (control group) consisted of twenty rat pups, born from the rats nourished ad libitum. Group 2 consisted of 18 newborn rats, born from the rats nourished ad libitum with 10% sun dried natural apricots. Group 3 consisted of 21 newborn rats, born from the rats nourished ad libitum. Subcutaneous (30nmol/gr) sodium selenite injection was applied to all the newborn rats except the control group (Group 1) on postpartum day 10. Cataract development was graded by slit-lamp examination and photography. Encapsulated lenses were analyzed for reduced glutathione (GSH) and malondialdehyde (MDA), a marker of lipid per oxidation. Lenses were also analyzed for total nitrite (TN). The presence of oxidative stress in selenite cataract development and its prevention by sun dried apricots.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23348406/