The differential modulatory effects ofon the gut microbiota of obese dogs and mice are associated with improvements in metabolic disturbances.

Abstract

Obesity is a disease in humans and companion animals that can cause many chronic diseases.() is a dominant fungus in Fuzhuan tea. In this study, we aimed to investigate the possibility thatmay reduce diet-induced obesity by regulating the gut microbiota and measuring the differences in the gut microbiota of obese mice and dogs undersupplementation. High-fat diet-fed C57BL/6J mice and beagle dogs were supplemented with livefor 8 or 12 weeks. Faecal microbiota transplantation (FMT) and 16S rRNA sequencing were used to evaluate the relationship between the anti-obesity effect ofand the gut microbiota. The results suggested that livereduced obesity and metabolic disorders in obese mice and dogs. 16S rRNA sequencing results revealed thatdecreased the Firmicutes/Bacteroidetes (F/B) ratio and the abundance of members of the Firmicutes phylum, including,, and, in obese mice, but the opposite was true in obese dogs. Furthermore, to investigate whether the antiobesity effect ofcan be attributed to gut microbiota, FMT and 16S rRNA sequencing were employed. The FMT trial confirmed that the anti-obesity effect ofwas mediated by modulating gut dysbiosis. In addition, we isolated livefrom faeces and found the β-hydroxy acid metabolite of monacolin K (MKA) inculture. Our research implies thathas the potential to treat obesity as a novel probiotic.