Peer-reviewed veterinary case report
The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation.
- Journal:
- IUBMB life
- Year:
- 2022
- Authors:
- Deng, Shin-Meng et al.
- Affiliation:
- Institute of Brain Science
- Species:
- rodent
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. Amyloid plaque-induced neuroinflammation exacerbates neurodegeneration and cognitive impairment in AD. To reduce neuroinflammation, we applied prebiotics or synbiotics to modulate the gut-brain axis in the AD mouse model. AD-like deficits were reduced in mice treated with synbiotics, suggesting that dietary modulation of the gut-brain axis is a potential approach to delay AD progression.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34962691/