Peer-reviewed veterinary case report
The anti-DNA knock-in model of systemic autoimmunity induced by the chronic graft-vs-host reaction.
- Journal:
- Methods in molecular medicine
- Year:
- 2004
- Authors:
- Eisenberg, Robert & Choudhury, Arpita
- Affiliation:
- Department of Medicine · United States
- Species:
- rodent
Abstract
The injection of spleen cells from bm12 mice into C57BL/6 recipients induces a chronic graft-vs-host reaction characterized by systemic autoimmunity, including anti-double-stranded DNA (anti-dsDNA) autoantibodies and immune complex-type proliferative glomerulonephritis. If the B6 recipient mice express an anti-DNA Vh site-directed transgene, the repertoire is skewed even more toward the anti-DNA response. Over a period of several weeks, high titers of serum anti-DNA antibodies appear and the mice develop renal damage. This permits the examination of the role of somatic immunoglobulin genetics and B-cell tolerance in a model of systemic lupus erythematosus.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15286390/