Peer-reviewed veterinary case report
Testing Nature's Defenses: Inducing Cancer in the Naked Mole Rat.
- Journal:
- Cancer discovery
- Year:
- 2026
- Authors:
- Boddy, Amy M & Abegglen, Lisa M
- Affiliation:
- University of California · United States
- Species:
- rodent
Abstract
Although mice develop lung cancer from a single Eml4-Alk driver fusion, Shepard, Lester, and colleagues show that naked mole rats require three simultaneous oncogenic events: Eml4-Alk, Tp53 loss, and Rb1 loss, achieving only 30% tumor penetrance. This inducible cancer model in naked mole rats offers a unique platform for uncovering mechanisms of cancer resistance and modeling rare pleomorphic lung carcinomas. See related article by Shepard et al., p. 35.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41521774/