Peer-reviewed veterinary case report
Testing Experimental Therapies in a Guinea Pig Model for Hemorrhagic Fever.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2018
- Authors:
- Wong, Gary et al.
- Affiliation:
- Institute of Microbiology · China
- Species:
- rodent
Abstract
Hemorrhagic fever viruses are among the deadliest pathogens known to humans, and often, licensed medical countermeasures are unavailable to prevent or treat infections. Guinea pigs are a commonly used animal for the preclinical development of any experimental candidates, typically to confirm data generated in mice and as a way to validate and support further testing in nonhuman primates. In this chapter, we use Sudan virus (SUDV), a lethal filovirus closely related to Ebola virus, as an example of the steps required for generating a guinea pig-adapted isolate that is used to test a monoclonal antibody-based therapy against viral hemorrhagic fevers.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28986842/