Peer-reviewed veterinary case report
Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor.
- Journal:
- European journal of pharmacology
- Year:
- 2006
- Authors:
- Izumi, Takeshi et al.
- Affiliation:
- Department of Psychiatry · Japan
- Species:
- rodent
Abstract
The purpose of the present study was to elucidate the brain regions in which citalopram, a selective serotonin reuptake inhibitor (SSRI), exerts its anxiolytic effects in conditioned fear stress (CFS) in rats, an animal model of anxiety. The effect of citalopram on CFS-induced c-Fos expression was investigated using immunohistochemistry. Systemic administration of citalopram attenuated contextual CFS-induced c-Fos expression in the secondary motor cortex, primary somatosensory cortex, and basolateral nucleus of the amygdala. Among these regions the basolateral nucleus of the amygdala is a likely candidate region in which citalopram exerts its anxiolytic effect.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16494863/