Peer-reviewed veterinary case report
Systemic gene transfer to skeletal muscle using reengineered AAV vectors.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2011
- Authors:
- Phillips, Jana L et al.
- Affiliation:
- University of North Carolina at Chapel Hill · United States
- Species:
- rodent
Abstract
Gene therapy of musculoskeletal disorders warrants efficient gene transfer to a wide range of muscle groups. Reengineered adeno-associated viral (AAV) vectors that selectively transduce muscle tissue following systemic administration are attractive candidates for such applications. Here we provide examples of several lab-derived AAV vectors that display systemic tissue tropism in mice. Methods to evaluate the efficiency of gene transfer to skeletal muscle following intravenous or isolated limb infusion of AAV -vectors in mice are discussed in detail.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21194026/