Peer-reviewed veterinary case report
Systemic Gene Therapy for Targeting the CNS.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2016
- Authors:
- Gombash, Sara E & Foust, Kevin D
- Affiliation:
- Department of Translational Science& Molecular Medicine · United States
- Species:
- rodent
Abstract
Systemic gene delivery is useful for modeling and treatment of a body-wide disease. Recently, it has been shown that certain agents, when delivered systemically, can efficiently target the central nervous system. This technique has been used to model and treat rodent models of neurological disease with unprecedented success. Here, we describe intravenous delivery in neonate and adult mice. These techniques are easily learned and have minimal equipment requirements.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26611590/