Peer-reviewed veterinary case report
Syndrome of inappropriate antidiuretic hormone secretion concurrent with liver disease in a dog.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2012
- Authors:
- Kang, Min-Hee & Park, Hee-Myung
- Affiliation:
- BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine · South Korea
- Species:
- dog
Plain-English summary
A 5-year-old female Chihuahua was brought to the vet after suddenly collapsing. Blood tests revealed very high levels of liver enzymes, but treatment with antibiotics for a liver infection didn't help. The dog's condition got worse, showing signs of low sodium levels in the blood and high sodium in the urine, leading to a diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH), which means her body was holding onto too much water. Further tests ruled out problems with her adrenal and thyroid glands, and brain issues were also excluded. After starting treatment with immunosuppressive medication and limiting her water intake, the dog's symptoms improved and the SIADH resolved.
Abstract
A 5-year-old female Chihuahua was presented for acute collapse. Laboratory examinations showed markedly elevated levels of hepatobiliary enzymes. Empiric antibiotic therapy for bacterial infection of the liver was ineffective. The clinical signs worsened with the development of hyponatremia with hypoosmolality and elevated urine sodium levels. The dog was suspected of having acute cholangiohepatitis associated with an immune-mediated disease. Subsequently, it was diagnosed with syndrome of inappropriate antidiuretic hormone secretion (SIADH) on the basis of the specific disease criteria. Further tests showed normal function of the adrenal and thyroid glands, and MRI and cerebrospinal fluid (CSF) analysis did not show any intracranial diseases. Immunosuppressive therapy and water restriction resolved the clinical signs and improved the SIADH in this dog. This case indicates that SIADH can occur concurrently with suspected immune-mediated liver disease in dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22185769/