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Peer-reviewed veterinary case report

Successful management of doxorubicin overdose and extravasation in a dog with lymphoma.

Journal:
The Canadian veterinary journal = La revue veterinaire canadienne
Year:
2018
Authors:
Kicenuik, Kristin S et al.
Affiliation:
Department of Small Animal Medicine and Surgery · United States
Species:
dog

Abstract

A dog was hospitalized after accidental overdose and extravasation of doxorubicin. With supportive care and dexrazoxane, systemic toxicity resolved by Day 9 and extravasation injury by Day 36. This case demonstrates that, with treatment, dogs can survive doxorubicin overdose and extravasation. The report also highlights the importance of checking the dose of chemotherapeutic agents and preventing extravasation.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/30510312/