Peer-reviewed veterinary case report
Study of cholesterol-lowering effect and safety of simvaglisin on rabbit model of hypercholesterolemia.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2008
- Authors:
- Ragino, Y I et al.
- Affiliation:
- N. N. Vorozhtsov Institute of Organic Chemistry
- Species:
- rabbit
Abstract
Using rabbit model of experimental hypercholesterolemia we showed that the hypocholesterolemic effect of simvaglisin, a complex preparation containing simvastatin and glycyrrhizic acid, in doses corresponding to 40, 66.5, and 100 mg/kg/day simvastatin is equal to the hypocholesterolemic effect of 200 mg/kg/day simvastatin alone. The total blood cholesterol decreased by 39, 36, 47, and 38% (p < 0.05), respectively, after 20-day course of the preparation. Myotoxicity of simvaglisin evaluated by serum creatine phosphokinase was lower than that of simvastatin. After 30-day treatment, this parameter was lower by 26, 24, and 29% (p < 0.05) than the corresponding parameter for simvastatin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19039932/