Peer-reviewed veterinary case report
Streptozotocin-induced sporadic Alzheimer's disease: selection of appropriate dose.
- Journal:
- Journal of Alzheimer's disease : JAD
- Year:
- 2013
- Authors:
- Mehla, Jogender et al.
- Affiliation:
- Department of Pharmacology · India
- Species:
- rodent
Abstract
The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular (ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of male Wistar rats was evaluated. Elevated plus maze, passive avoidance, and Morris water maze tests were used to assess the cognitive functions. A significant cognitive deficit was found at the 2nd week onwards, which persisted up to the 14th week with single and twice ICV-STZ (3 mg/kg) injections, whereas no cognitive impairment was found in ICV-STZ (1 mg/kg) treated groups after 8-10 weeks.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22886014/