Peer-reviewed veterinary case report
Streptozotocin-Induced Diabetic Models in Mice and Rats.
- Journal:
- Current protocols in pharmacology
- Year:
- 2015
- Authors:
- Furman, Brian L
- Affiliation:
- Strathclyde Institute of Pharmacy & Biomedical Sciences · United Kingdom
- Species:
- rodent
Abstract
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ-induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26331889/