Peer-reviewed veterinary case report
Simultaneous orthotopic transplantation of carotid and aorta in the rat by the sleeve technique.
- Journal:
- Laboratory animals
- Year:
- 2002
- Authors:
- Labat, A et al.
- Affiliation:
- Department of Experimental Surgery · France
- Species:
- rodent
Plain-English summary
This study looked at a new way to transplant blood vessels in rats to better understand issues that can arise after organ transplants. Researchers performed surgeries on 25 rats to connect the aorta and carotid arteries at the same time using a special technique. They did not give the rats any medication to suppress their immune systems, and most of the rats survived for the duration of the study, which was up to 60 days. The results showed that the transplanted vessels developed typical problems associated with graft vascular disease, which is a common concern after organ transplants. Overall, this new method of surgery could help scientists learn more about the factors that affect the success of transplants.
Abstract
Graft vascular disease (GVD) remains the major limitation to long-term survival after solid organ transplantation. Aortic or carotid allografts in rats have been shown to be useful models because similar changes to those observed in man develop within weeks. Both immunological and non-immunological factors influence the process of GVD and a method that could permit rapid multiple arterial allotransplantation in the rat would be of great value. We performed simultaneous orthotopic aortic and carotid allotransplantations in 25 rats. The vessels were anastomosed using a sleeve technique. No immunosuppression was given. The animals were killed at 15, 30, or 60 days and histological analyses of the grafts were performed. The overall survival rate was 80% and the incidence of technical failure was very low. The histopathological aspect revealed typical progressive GVD. In conclusion, we have developed a new model of simultaneous aortic and carotid transplantation in rats. This model, which incorporates a modification of the sleeve anastomosis, is rapid and yields an easy tool to investigate immunological and non-immunological processes driving GVD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/12396286/