Peer-reviewed veterinary case report
Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm.
- Journal:
- Epilepsia
- Year:
- 2011
- Authors:
- Bajorat, Rika et al.
- Affiliation:
- Oscar Langendorff Institute of Physiology · Germany
- Species:
- rodent
Abstract
Pilocarpine-induced status epilepticus (SE) results in chronic spontaneous recurrent seizures resembling human temporal lobe epilepsy. In this and other experimental models, behaviorally monitored seizure frequency was suggested to vary in a circadian fashion, and to increase with time. We re-addressed those hypotheses using continuous video-electroencephalography (EEG) telemetry in rats with SE at 30 days of age. In 11 chronically epileptic animals monitored up to 300 days after SE in a fixed 12 h light/dark cycle, we found that seizure frequency did not correlate with circadian rhythm.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21801169/