Peer-reviewed veterinary case report
Safety Evaluation of Autologous Tissue Vaccine Cancer Immunotherapy in a Canine Model.
- Journal:
- Anticancer research
- Year:
- 2019
- Authors:
- Crossley, Rachel A et al.
- Affiliation:
- Department of Pathobiology and Veterinary Science · United States
- Species:
- dog
Abstract
BACKGROUND/AIM: Previous work in rodent models showed that an autologous tissue vaccine is both a safe and effective approach for treating cancer; however, as a translational step, safety must first be evaluated in a more clinically-relevant model. MATERIALS AND METHODS: An autologous immunotherapy produced from resected tumors, was evaluated in a clinically-relevant canine model to assess safety. Ninety-three dogs with spontaneously occurring tumors received vaccination with inactivated autologous tumor tissue combined with an adjuvant of particulate porcine small intestinal submucosa extracellular matrix (SIS-ECM). Patients were followed to assess the occurrence of adverse events, overall survival, and tumor recurrence and/or metastasis. RESULTS: A small number (12%) of patients experienced limited, mild pyrexia, injection site swelling, or lethargy, all resolving without clinical intervention. CONCLUSION: Autologous whole cell cancer immunotherapy can be used safely in the canine model of cancer and represents a safe approach for the treatment for cancer.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30952708/