Peer-reviewed veterinary case report
Retrospective outcome evaluation for dogs with surgically excised, solitary Kiupel high-grade, cutaneous mast cell tumours.
- Journal:
- Veterinary and comparative oncology
- Year:
- 2020
- Authors:
- Moore, Antony S et al.
- Affiliation:
- Veterinary Oncology Consultants · United Kingdom
- Species:
- dog
Plain-English summary
This study looked at the outcomes for 49 dogs with a specific type of skin cancer called Kiupel high-grade cutaneous mast cell tumors (MCTs) that were surgically removed. On average, these dogs lived about 1046 days after surgery, with most surviving for at least a year or two. However, some dogs faced issues like the tumor coming back, spreading to lymph nodes, or developing new tumors. The research found that dogs with smaller tumors and lower cell division rates (mitotic counts) tended to live longer, suggesting that these factors are important for predicting how well a dog might do after treatment. Overall, the findings indicate that while many dogs can have a good survival time after surgery, it's crucial to consider more than just the tumor's grade when discussing prognosis with your veterinarian.
Abstract
Published outcomes for dogs with specifically high-grade mast cell tumours (MCTs), controlled for clinical stage, are few. Clinical outcomes for 49 dogs with Kiupel high-grade, clinical stage I, cutaneous MCTs were evaluated. Median survival time (MST) was 1046 days; 1 and 2-year survival rates were 79.3% and 72.9%, respectively. At study end 24 dogs had died, 23 dogs were alive (median follow-up 980 days) and 2 dogs were lost to follow-up. Death was considered MCT-related in 14 of 20 dogs with a known cause of death. Local tumour recurrence developed in nine dogs (18.4%); regional lymph node metastasis occurred in six dogs (12.2%); and a new MCT developed in 15 dogs (30.1%). Tumour location, histologic margin size and use of chemotherapy did not affect MST; increasing mitotic count (P = .001) and increasing tumour diameter (P = .024) were independently negatively prognostic. Six dogs that developed lymph node metastasis after surgery had worse MST (451 days) than 42 dogs that did not develop metastasis (1645 days); (P < .001). Our study suggests that dogs with local surgical control of clinical stage I histologically high Kiupel grade cutaneous MCT may have a long survival time; especially those with smaller tumours and a lower mitotic count. Our results suggest that evaluation of staging information and mitotic count may be equally helpful as histologic grading when making a prognosis; and highlight the importance of not relying on histologic grade alone when predicting survival for dogs with MCT.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31916687/