Peer-reviewed veterinary case report
Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain.
- Journal:
- Brain research
- Year:
- 2006
- Authors:
- Bean, LeDon et al.
- Affiliation:
- Department of Pharmacology and Experimental Neuroscience · United States
- Species:
- rodent
Abstract
Insulin insufficiency has multiple actions on the CNS. Three weeks after streptozotocin-induced diabetes in rats, we found a preferential downregulation of l-[(3)H]glutamate-labeled NMDA receptors in primary sensory cortical regions. Layers I-III of the parietal cortex and superficial piriform cortex were the most sensitive followed by other cortical regions and, in turn, deeper brain structures. These effects on NMDA receptors can potentially explain some of the known CNS effects of diabetes.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16938282/