Peer-reviewed veterinary case report
Refractory seizures associated with an organic aciduria in a dog.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2007
- Authors:
- Platt, Simon et al.
- Affiliation:
- Department of Small Animal Medicine · United States
- Species:
- dog
Plain-English summary
A 6-month-old female Cavalier King Charles spaniel had seizures that were hard to manage with regular medications for a whole year. When she was 20 months old, vets discovered she had an organic aciduria, which means her body was producing too much of a substance called hexanoylglycine. After trying different treatments, her seizures became more manageable when they added levetiracetam to her existing medications, potassium bromide and phenobarbital. Overall, the treatment worked to control her seizures better.
Abstract
A 6-month-old, female Cavalier King Charles spaniel exhibited seizures that were difficult to control with standard anticonvulsants over a 12-month period. The diagnosis of an organic aciduria with excessive excretion of hexanoylglycine was determined when the dog was 20 months old. Recurrent and cluster seizures were eventually controlled with the addition of levetiracetam to potassium bromide and phenobarbital.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17473023/