Peer-reviewed veterinary case report
Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats.
- Journal:
- Oncotarget
- Year:
- 2015
- Authors:
- Lesovaya, Ekaterina A et al.
- Affiliation:
- Department of Chemical Carcinogenesis
- Species:
- rodent
Abstract
Benign prostatic hyperplasia (BPH) is the most common age-related disease in men. Here we tested the efficacy of Rapatar, a micellar nanoformulation of rapamycin, in two rat models of BPH: testosterone-induced and sulpiride-induced hyperplasia in ventral lobes and lateral/dorsal lobes, respectively. We found that Rapatar prevented hypertrophic and hyperplastic abnormalities and degenerative alterations in both BPH models. Rapatar normalized weight of the lateral lobes in sulpiride-induced BPH, the most relevant animal model of human BPH. Unlike Finasteride, a standard therapy of BPH, Rapatar reduced inflammation caused by sulpiride. No obvious side effects of Rapatar were detected. Our data provide a rationale for clinical trials of Rapatar in patients suffering from BPH.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25991667/