Peer-reviewed veterinary case report
Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.
- Journal:
- Infection and immunity
- Year:
- 2005
- Authors:
- Clark, Catherine J et al.
- Affiliation:
- Institute of Biomedical and Life Sciences · United Kingdom
- Species:
- rodent
Abstract
C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hydroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16041050/