Progressive Cutaneous Angiomatosis in a Persian Cat: Case Report

Abstract

Angiomatosis is a vascular disorder characterized by proliferative granulation tissue formation, with the growth of angioblastic cells surpassing that of fibroblasts, resulting in inflammatory connective tissue with a tendency for spontaneous bleeding. It is a rare pathology in veterinary medicine, and its pathogenesis remains poorly understood. Therefore, the objective of this study is to report a case of angiomatosis where the diagnostic confirmation was achieved through histopathological examination. A female Persian cat, one year old, was presented with lameness, marked edema, and active bleeding in the distal region of the left thoracic limb, with symptoms persisting for several months. Physical examination revealed ulcerated skin lesions with bloody crusts, areas of hyperpigmentation, and extensive hematomas. An incisional biopsy was performed, and the samples were sent for histopathological examination. Microscopic evaluation revealed a low-grade vascular proliferation involving the superficial, perianexial, and deep dermis. The cells exhibited oval nuclei with mild anisocaryosis, stippled chromatin, and an absence of mitotic figures, consistent with the morphological appearance of progressive cutaneous angiomatosis. Treatment involved limb amputation