Peer-reviewed veterinary case report
Prion-induced amyloid heart disease with high blood infectivity in transgenic mice.
- Journal:
- Science (New York, N.Y.)
- Year:
- 2006
- Authors:
- Trifilo, Matthew J et al.
- Affiliation:
- Scripps Research Institute · United States
- Species:
- rodent
Abstract
We investigated extraneural manifestations in scrapie-infected transgenic mice expressing prion protein lacking the glycophosphatydylinositol membrane anchor. In the brain, blood, and heart, both abnormal protease-resistant prion protein (PrPres) and prion infectivity were readily detected by immunoblot and by inoculation into nontransgenic recipients. The titer of infectious scrapie in blood plasma exceeded 10(7) 50% infectious doses per milliliter. The hearts of these transgenic mice contained PrPres-positive amyloid deposits that led to myocardial stiffness and cardiac disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16825571/