Peer-reviewed veterinary case report
Prevalence of equine herpesvirus type 1 strains of neuropathogenic genotype in a major breeding area of Japan.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2011
- Authors:
- Tsujimura, Koji et al.
- Affiliation:
- Equine Research Institute · Japan
- Species:
- horse
Abstract
A single non-synonymous nucleotide substitution of guanine (G) for adenine (A) at position 2254 in the viral DNA polymerase gene (encoded by open reading frame [ORF] 30) of equine herpesvirus type 1 (EHV-1) has been significantly associated with neuropathogenic potential in strains of this virus. To estimate the prevalence of EHV-1 strains with the neuropathogenic genotype (ORF30 G(2254)) in the Hidaka district--a major horse breeding area in Japan--we analyzed the ORF30 genomic region in cases of EHV-1 infection in this area during the years 2001-2010. Of the 113 cases analyzed, 3 (2.7%) were induced by ORF30 G(2254) strains. This prevalence is lower than those observed in the U.S.A. (10.8-19.4%), Argentina (7.4%), France (24%), and Germany (10.6%).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21828961/