Peer-reviewed veterinary case report
Presumptive precursor-targeted immune-mediated anemia concurrent with gastrointestinal lymphoma in a cat.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2020
- Authors:
- Akiyoshi, Makoto et al.
- Affiliation:
- Azabu University · Japan
- Species:
- cat
Plain-English summary
A 10-year-old spayed female mixed-breed cat was brought to the vet because she was very tired and had severe anemia, which means her blood wasn't carrying enough oxygen. Tests showed she had a mass in her stomach and her bone marrow was producing fewer red blood cells than normal. The cat was diagnosed with a type of anemia caused by her immune system attacking her own blood cells, and she also had a type of cancer called T-cell lymphoma in her stomach. After surgery to remove the lymphoma and treatment to suppress her immune system, both conditions were successfully treated, and as of 410 days later, she has not had any relapses without needing medication.
Abstract
A 10-year-old spayed female mixed-breed cat presented with progressive nonregenerative anemia. Clinicopathological abnormalities included severe nonregenerative anemia (packed cell volume [PCV]: 7%, aggregate reticulocytes: 1.12 × 10/µl) and a hypoechogenic mass well-localized in the stomach. Bone marrow (BM) smears revealed increased particle hematopoietic cellularity with decreased myeloid:erythroid (M:E) ratios, no dysplasia of any lineage, and presence of erythroid precursors phagocytized by macrophages. The cat was diagnosed with presumptive precursor-targeted immune-mediated anemia (PIMA). The stomach mass was consistent with CD 20 positive T-cell lymphoma. The lymphoma was completely resected via surgery, and the PIMA was cured by immunosuppressive therapy. On day 410, both diseases have not recurred without medications. This is the first report of feline PIMA and concurrent gastrointestinal lymphoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32863286/