Peer-reviewed veterinary case report
Presumed primary ocular lymphangiosarcoma with metastasis in a miniature horse.
- Journal:
- Veterinary ophthalmology
- Year:
- 2015
- Authors:
- Gerding, Joseph C et al.
- Affiliation:
- Department of Clinical Sciences · United States
- Species:
- horse
Plain-English summary
A 7-year-old American Miniature mare was brought in because she had an eye condition called keratoconjunctivitis, which means her right eye was inflamed. During the examination, a mass was found on the conjunctiva (the membrane covering the eye) and she was diagnosed with a type of cancer called angiosarcoma. After surgery to remove the eye, the mare developed nosebleeds and swelling around her eye, and further tests showed that the cancer had spread to other areas. Sadly, due to the severity of her condition, she was humanely euthanized, and the examination after death confirmed that the cancer had spread significantly.
Abstract
A 7-year-old, 153.0-kg American Miniature mare presented for evaluation of keratoconjunctivitis of the right eye (OD). A superior palpebral conjunctival mass and stromal keratitis were diagnosed. The incisional biopsy diagnosis was a presumptive corneal hemangiosarcoma. Transpalpebral enucleation was performed, and histopathologic evaluation confirmed angiosarcoma of the conjunctiva, cornea, and extraocular muscles. The horse developed progressive epistaxis and orbital swelling following surgery. A systemic workup was performed 3 months after enucleation, revealing regrowth within the orbit and marked cranial cervical lymphomegaly, suggestive of metastasis. Humane euthanasia was performed, and necropsy confirmed a locally invasive periorbital tumor with metastasis to the submandibular tissue, submandibular lymph node, and thoracic inlet. Histopathologic evaluation of necropsy specimens revealed polygonal to spindle neoplastic cells lining neoplastic vascular channels lacking erythrocytes. Immunohistochemically, the neoplastic cells labeled strongly positive for PROX-1, vimentin, CD-31, VEGF, weakly positive for factor VIII-related antigen, and negative for collagen IV. Based on the clinical, histological, and immunohistochemical features of this tumor, a primary ocular lymphangiosarcoma with metastasis was diagnosed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25581559/