Peer-reviewed veterinary case report
Preliminary study of urinary excretion of liver-type fatty acid-binding protein in a cat model of chronic kidney disease.
- Journal:
- Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
- Year:
- 2021
- Authors:
- Watanabe, Akiko et al.
- Affiliation:
- Graduate School of Veterinary Sciences · Japan
- Species:
- cat
Abstract
Urinary liver-type fatty acid-binding protein (uL-FABP) is a clinically useful biomarker for monitoring chronic kidney disease (CKD) in humans. However, long-term monitoring of uL-FABP in CKD cats has not been reported. The objective of this preliminary study was to investigate whether the urinary excretion of L-FABP could predict the deterioration of renal function in 2 CKD model cats. Urinary liver-type fatty acid-binding protein (uL-FABP) increased before standard renal biomarkers, including serum creatinine, blood urea nitrogen, and symmetric dimethylarginine, in 1 cat with deteriorating renal function, but remained low and relatively stable in another cat with stable renal function. Our results suggest that uL-FABP is a potential clinical biomarker for predicting the progression of CKD in cats, as it is in humans.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33883825/