Peer-reviewed veterinary case report
Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs.
- Journal:
- Frontiers in veterinary science
- Year:
- 2023
- Authors:
- Yun, Taesik et al.
- Affiliation:
- College of Veterinary Medicine · South Korea
- Species:
- dog
Abstract
Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs ( = 6, 175.5 pg/mL) than in healthy dogs ( = 15, 15.9 pg/mL; < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37901103/