Peer-reviewed veterinary case report
Practical murine hematopathology: a comparative review and implications for research.
- Journal:
- Comparative medicine
- Year:
- 2015
- Authors:
- O'Connell, Karyn E et al.
- Affiliation:
- Department of Comparative Pathology · United States
- Species:
- rodent
Plain-English summary
This study looks at how blood-related health issues in mice can help us understand diseases in both humans and pets. Mice have different blood characteristics compared to humans and other animals, such as smaller red blood cells and different types of white blood cells. These differences are important to consider when studying diseases and testing new treatments. The researchers emphasize that knowing these unique features of mouse blood health can improve research outcomes. Overall, this review aims to help scientists and veterinarians better translate findings from mouse studies to other species.
Abstract
Hematologic parameters are important markers of disease in human and veterinary medicine. Biomedical research has benefited from mouse models that recapitulate such disease, thus expanding knowledge of pathogenetic mechanisms and investigative therapies that translate across species. Mice in health have many notable hematologic differences from humans and other veterinary species, including smaller erythrocytes, higher percentage of circulating reticulocytes or polychromasia, lower peripheral blood neutrophil and higher peripheral blood and bone marrow lymphocyte percentages, variable leukocyte morphologies, physiologic splenic hematopoiesis and iron storage, and more numerous and shorter-lived erythrocytes and platelets. For accurate and complete hematologic analyses of disease and response to investigative therapeutic interventions, these differences and the unique features of murine hematopathology must be understood. Here we review murine hematology and hematopathology for practical application to translational investigation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25926395/