Peer-reviewed veterinary case report
Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters.
- Journal:
- Oral surgery, oral medicine, oral pathology and oral radiology
- Year:
- 2014
- Authors:
- Horii, Koichiro et al.
- Affiliation:
- Department of Oral and Maxillofacial Surgery · Japan
- Species:
- rodent
Abstract
OBJECTIVE: The aim of this study was to evaluate the healing effect of topically applied platelet-rich fibrin (PRF) on experimental oral mucositis induced by chemotherapy in hamsters. STUDY DESIGN: Oral mucositis was induced in 93 Syrian golden hamsters by an intraperitoneal injection of 5-fluorouracil, which was followed by light scratching of the cheek pouch. The hamsters were randomly divided into a PRF group, a fibrin group, and an untreated control group. The recovery stage of oral mucositis was evaluated through daily weighing, measurements of the ulcer area, histopathologic analysis, and a myeloperoxidase activity assay. RESULTS: The PRF group exhibited significant improvements in the size and histologic features of the ulcer and in the myeloperoxidase activity compared with the control group (P < .05). CONCLUSIONS: The current findings suggest the consideration for future clinical trials in humans.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24485786/