Peer-reviewed veterinary case report
Pharmacovigilance in veterinary medicine in Chile: a pilot study.
- Journal:
- Journal of veterinary pharmacology and therapeutics
- Year:
- 2011
- Authors:
- Iragüen, D et al.
- Affiliation:
- Department of Clinical Sciences
- Species:
- dog
Plain-English summary
In Chile, there currently isn't a system in place to track and analyze negative reactions to medications in pets. A recent study looked into how often these reactions happen in cats and dogs over a six-month period. They found a total of 149 cases of adverse drug reactions (ADRs), with only 29 reported through official forms, indicating that many cases go unreported. Most of these reactions were linked to common medications like antibiotics, vaccines, and sedatives. The findings suggest that there is a strong need for a program to monitor these reactions in veterinary medicine to improve the safety of medications for pets.
Abstract
Iragüen, D., Urcelay, S., San Martín, B. Pharmacovigilance in veterinary medicine in Chile: a pilot study. J. vet. Pharmacol. Therap.34, 108-115. In Chile, there is no present government policy to survey and analyse adverse drug reactions (ADRs) in the field of veterinary medicine. The intent of this study is to assess, for the first time, ADR frequency in treated animals. To this purpose, a 6-month period pilot study based on WHO recommendations was conducted to monitor ADRs in cats and dogs for frequently used drugs and common labelled signs. Of a total of 149 detected ADRs, 29 (6 in cats and 23 in dogs) were notified by means of ADR report forms, while the rest was identified after reviewing patient clinical records, thus evidencing strong under-reporting problems. More than 70% of ADRs were related to antimicrobials, vaccines and tranquilizers. In dogs, there was a significant effect on ADRs' presentation when acepromazine, amoxicillin, carprofen, ivermectin, sextuple vaccine (polyvalent vaccine that confers immunity against canine distemper virus, canine parvovirus, Leptospira canicola, L. icterohemmoragiae, canine adenovirus type 2 and canine parainfluenza virus) and phytomenadione (subcutaneous injection) were administered. In the case of cats, a significant influence on ADRs was detected when acepromazine, amoxicillin or vitamin K was administered. Present results suggest the need for a pharmacovigilance programme in veterinary medicine for timely ADR-presenting drug detection and drug safety improvement.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21395600/