Peer-reviewed veterinary case report
Pharmacological efficacy of argemone mexicana plant extract, against cysteamine-induced duodenal ulceration in rats.
- Journal:
- Indian journal of medical sciences
- Year:
- 2011
- Authors:
- Das, Prabhat K et al.
- Affiliation:
- Department of Pharmacology · India
- Species:
- rodent
Abstract
OBJECTIVE: The plant Argemone mexicana is traditionally used as diuretic, anti-inflammatory, antibacterial, antifungal agent, and has wound-healing property. This study was carried out to evaluate the effect of A. mexicana aerial part of the plant (methanolic and aqueous extract p.o.) on duodenal ulceration. MATERIALS AND METHODS: The study was carried out on the duodenal ulceration model by using cysteamine hydrochloride. Ranitidine (20 mg/kg) was used as standard drug. RESULTS: Both the extracts of the plant A. mexicana produced a significant activity in cysteamine-induced duodenal ulceration. The aqueous extract at the dose-dependent manner showed the potent activity than methanolic extract. CONCLUSION: The plant A. mexicana Linn. Increased healing of gastric ulceration and prevented the development of experimentally induced duodenal ulceration in rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23250289/