Peer-reviewed veterinary case report
Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis.
- Journal:
- The journal of vascular access
- Year:
- 2014
- Authors:
- Roy-Chaudhury, Prabir et al.
- Affiliation:
- University of Cincinnati · United States
Abstract
PURPOSE: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. METHODS: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. RESULTS: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. CONCLUSION: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24043320/