Peer-reviewed veterinary case report
PAS-positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque.
- Journal:
- Journal of medical primatology
- Year:
- 2014
- Authors:
- Hong, Jung Joo et al.
- Affiliation:
- Division of Pathology · United States
Abstract
BACKGROUND: Lymphoid tissue remodeling is characteristic of chronic simian immunodeficiency virus infection. METHODS: A rhesus macaque infected with SIVmac239 was necropsied and its lymphoid tissues subjected to histopathology characterization. RESULTS: Germinal centers in spleen and lymph nodes contained PAS-positive, non-amyloid extracellular deposits, decreased T follicular helper cells, and normal density of Ki67(+) B cells. CONCLUSIONS: A possible mechanism for PAS-positive deposits includes exaggerated involution of SIV-induced follicular hyperplasia secondary to virus-associated immune reaction.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24628065/