Peer-reviewed veterinary case report
Oxidative damage of periodontal tissue in the rat periodontitis model: effects of a high-cholesterol diet.
- Journal:
- FEBS letters
- Year:
- 2006
- Authors:
- Tomofuji, Takaaki et al.
- Affiliation:
- Department of Oral Health · Japan
- Species:
- rodent
Abstract
Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16750199/