Outcome of three dogs with respiratory epithelial adenomatoid hamartoma and chondroosseous respiratory epithelial adenomatoid hamartoma treated with radiotherapy.

Abstract

Intranasal respiratory epithelial adenomatoid hamartomas (REAHs) and chondro-osseous respiratory epithelial adenomatoid hamartomas (COREAHs) are rare in dogs. Affected dogs are often treated surgically but published outcomes data are scant. Here, 3 cases are described. An 11-year-old Siberian Husky with advanced REAH underwent stereotactic radiosurgery (17 Gy); had no acute radiotoxicity and experienced short-lived clinical improvement before loss to follow-up. An 8-year-old mixed breed dog with advanced COREAH causing cribriform lysis received stereotactic body radiotherapy (SBRT) (30 Gy in 3 fractions); had no acute radiotoxicity, a strong partial response to treatment, and was euthanized 26 months after irradiation. A 5-year-old Border Collie with sinonasal COREAH and cribriform lysis was treated with 3D conformal radiotherapy (45 Gy in 12 fractions); the dog had stable disease for 18 months with ongoing follow up at the time of publication. These experiences provide evidence that REAH/COREAH could be radioresponsive with potential for prolonged survival.