Peer-reviewed veterinary case report
Osseous metaplasia within a canine insulinoma
- Journal:
- Veterinary Clinical Pathology
- Year:
- 2014
- Authors:
- Pieczarka, Emily M. et al.
- Affiliation:
- Department of Veterinary Biosciences College of Veterinary Medicine The Ohio State University Columbus OH USA · United States
- Species:
- dog
Plain-English summary
An 11-year-old male mixed-breed dog was brought in because he was very tired, had trouble walking, and was experiencing low blood sugar levels. An ultrasound of his abdomen showed two lumps in the pancreas, and tests on one of these lumps suggested it was a type of cancer called insulinoma, which affects hormone-producing cells. Further examination confirmed this diagnosis and also revealed that a significant part of the tumor had turned into bone tissue, which is unusual for this type of cancer. This case is notable because it is the first time such a change has been reported in an insulinoma.
Abstract
AbstractAn 11‐year‐old male castrated mixed‐breed dog was presented for exercise intolerance, tetraparesis, and persistent hypoglycemia. Abdominal ultrasound examination revealed 2 nodules within the right limb of the pancreas. Cytology from one nodule was consistent with a carcinoma of neuroendocrine origin, with a primary differential diagnosis of insulinoma. Histologic evaluation and immunohistochemistry for synaptophysin and insulin confirmed the diagnosis of insulinoma. Additionally, there was a solitary nodule of mineralized compact bone composing approximately 60% of the mass. To the authors' knowledge, this is the first report of osseous metaplasia within an insulinoma (islet cell carcinoma).
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Search related cases →Original publication: https://doi.org/10.1111/vcp.12117