Peer-reviewed veterinary case report
Novel inhalational murine model of invasive pulmonary aspergillosis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2004
- Authors:
- Sheppard, Donald C et al.
- Affiliation:
- Department of Medicine · United States
- Species:
- rodent
Abstract
We developed a novel model of invasive aspergillosis (IA) that recapitulates human disease. Mice were immunosuppressed with cyclophosphamide and cortisone acetate and then infected in an aerosol chamber. This procedure reproducibly delivered 1 x 10(3) to 3 x 10(3) conidia to the lungs. Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15105158/