Peer-reviewed veterinary case report
Neutralization of interleukin-10 significantly enhances gamma interferon expression in peripheral blood by stimulation with Johnin purified protein derivative and by infection with Mycobacterium avium subsp. paratuberculosis in experimentally infected cattle with paratuberculosis.
- Journal:
- Infection and immunity
- Year:
- 2004
- Authors:
- Buza, Joram J et al.
- Affiliation:
- National Institute of Animal Health. Molecular Immunology Laboratory · Japan
Abstract
Monoclonal antibody neutralization of interleukin-10 (IL-10) increased Johnin purified protein derivative-induced whole-blood gamma interferon (IFN-gamma) secretion 23-fold and also increased IFN-gamma secretion ninefold following in vitro Mycobacterium avium subsp. paratuberculosis infection of peripheral blood mononuclear cells. These results demonstrate the suppressive effect of IL-10 on immune responses to M. avium subsp. paratuberculosis infection in cattle.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15039374/