Peer-reviewed veterinary case report
Nesidioblastosis and Subsequent Diabetes Mellitus in a Dog with Hyperinsulinemic Hypoglycemia Treated with Partial Pancreatectomy.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2024
- Authors:
- Arjoonsingh, Avin et al.
- Affiliation:
- From the College of Veterinary Medicine · United States
- Species:
- dog
Plain-English summary
A 6.5-year-old male mixed-breed dog was brought to the vet because he was showing signs of low blood sugar, which is called hypoglycemia. After some tests, the vet found that the dog had a condition called hyperinsulinemic hypoglycemia, where his body was producing too much insulin. Although no obvious tumor was found in his pancreas, the vet performed surgery to remove part of it, suspecting it might help. After the surgery, the dog’s blood sugar levels returned to normal, but two years later, he was diagnosed with diabetes mellitus, which means he now has trouble managing his blood sugar levels.
Abstract
A 6.5 yr old castrated male mixed-breed dog was presented for clinical signs associated with hypoglycemia. Hyperinsulinemic hypoglycemia was diagnosed as the cause of the persistent hypoglycemia. No obvious pancreatic mass was seen on abdominal computed tomography and exploratory laparotomy. A partial pancreatectomy was performed with the suspicion of an insulinoma-causing hyperinsulinemic hypoglycemia. Nesidioblastosis was diagnosed based clinical, biochemical, and histopathologic findings. There was beta cell hyperplasia and no evidence of neoplasia. The dog was euglycemic postoperatively after a partial pancreatectomy. Long-term follow-up after 2 yr revealed that the dog was diagnosed with diabetes mellitus.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38175975/