Peer-reviewed veterinary case report
Nef-specific CD107aCD4T-cell responses in a rhesus macaque (Macaca mulatta) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion.
- Journal:
- Journal of medical primatology
- Year:
- 2022
- Authors:
- Hau, Trang Thi Thu et al.
- Affiliation:
- National Institute of Infectious Diseases · Japan
Abstract
Acute-phase neutralizing antibody (NAb) passive immunization in simian immunodeficiency virus (SIV)-infected rhesus macaques (Macaca mulatta) can confer stringent viremia control with T-cell augmentation. In one NAb-infused SIV partial controller, we identify chronic-phase Nef-specific CD107aCD4T-cell response maintenance, implicating that NAb infusion modulates long-term T-cell responses even within viremic control.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34750827/