Peer-reviewed veterinary case report
N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat.
- Journal:
- Clinical and experimental hypertension (New York, N.Y. : 1993)
- Year:
- 2006
- Authors:
- Mondo, Charles K et al.
- Affiliation:
- Institute of Cardiology · China
- Species:
- rodent
Abstract
We investigated the effect of antioxidant N-acetylcysteine (NAC) on adrenocorticotropic hormone (ACTH)-hypertension. Male Sprague-Dawley rats received NAC (10 mg/L) or water 4 days before ACTH/saline treatment for 13 days (prevention study). In a reversal study, NAC commenced on day 8 of ACTH/saline treatment and continued for 5 days. ACTH increased systolic blood pressure (SBP) in water drinking rats (111 +/- 1 to 131 +/- 3 mmHg, p < 0.001). In the prevention study, NAC + ACTH increased SBP (108 +/- 2 to 120 +/- 2 mmHg, p < 0.001) but less than ACTH alone (p' < 0.05). In the reversal study, NAC had no significant effect (132 +/- 4 to 124 +/- 3 mmHg, ns). Thus, NAC partially prevented but did not reverse ACTH-induced hypertension.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16546835/