Peer-reviewed veterinary case report
Myelin composition of spinal cord in a model of amyotrophic lateral sclerosis (ALS) in SOD1G93A transgenic rats.
- Journal:
- Folia neuropathologica
- Year:
- 2007
- Authors:
- Niebroj-Dobosz, Irena et al.
- Affiliation:
- Neuromuscular Unit Medical Research Centre
- Species:
- rodent
Abstract
We present the results of biochemical and electron microscopic (EM) examinations of the spinal cord myelin from SOD1G93A transgenic Sprague Dawley rats in the early and late symptom-free period of the disease (60 and 93 days of life) and after four-leg paralysis has occurred (120 days of life). Biochemical and ultrastructural changes of myelin started already in the symptom-free period and become most pronounced in the paralyzed animals. Biochemical examinations indicated a decrease of lipids, phospholipids, cholesterol and cerebrosides. The pattern of particular phospholipids was in the normal range. A progressive decrease of the percentages of proteolipid, DM-20 and Wolfgram proteins was evident. Myelin basic proteins I and II were less affected. In EM,massive myelin disorganization was observed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18176898/