Murine models of lung adenocarcinoma: Valuable tools for preclinical investigation.

Abstract

Lung adenocarcinoma (LUAD) is a primary subtype of non-small cell lung cancer (NSCLC), notorious for its high mortality due to metastasis and poor prognosis. Utilizing various mouse models to simulate human LUAD is essential for advancing understanding of its mechanisms and developing new treatments. This review examines tumor mouse models commonly used in LUAD research, including cell-derived xenografts (CDX), patient-derived xenografts (PDX), carcinogen-induced models, and genetically engineered mouse models (GEMM). We discuss the suitability, benefits, and limitations of each model, and proposes using a combination of models to enhance research relevance for human LUAD, aiding in the discovery of new drugs and personalized treatments.