Peer-reviewed veterinary case report
Multiple peripheral nerve sheath tumors in the small intestine of a horse.
- Journal:
- Veterinary pathology
- Year:
- 1996
- Authors:
- Kirchhof, N et al.
- Affiliation:
- Institut fü · Germany
- Species:
- horse
Plain-English summary
A 6-year-old pinto gelding horse was brought in because he had a sudden episode of colic, which is a type of belly pain. During surgery, veterinarians found and removed about three meters of his small intestine, where they discovered several benign tumors called neurofibromas and schwannomas, as well as some enlarged nerve clusters. These tumors were located near a small pouch in the intestine and were well-defined, meaning they had clear borders. After examining the tissue under a microscope and using special staining techniques, the veterinarians confirmed that these tumors were benign peripheral nerve sheath tumors. The treatment involved surgery to remove the affected part of the intestine, and the tumors were found to be non-cancerous.
Abstract
Multiple neurofibromas, schwannomas, and hyperplastic enteric plexuses were observed in the distal jejunum and ileum of a 6-year-old pinto gelding. The animal was presented because of an acute episode of colic. Three meters of distal small intestine, partially incarcerated in the epiploic foramen, were surgically removed. Numerous tumor nodules up to 10 mm in diameter were found adjacent to a Meckel's diverticulum, predominantly located in the subserosa of a hypertrophic segment. Histologically, tumors were well demarcated and composed of interlacing fascicles formed by spindloid cells. Adjacent enteric plexuses were hyperplastic. Immunohistochemically, all tumors were positive for vimentin and S-100. Desmin immunoreactivity was only observed in larger tumors (> 500 microns). Glial fibrillary acid protein was demonstrated nearly exclusively in smaller ones. Immunostaining for neurofilament was restricted to entrapped ganglion cells. Based on conventional light microscopic examination and immunohistochemical evaluation, the lesion was diagnosed as multiple benign peripheral nerve sheath tumors in the small intestine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8952038/