Peer-reviewed veterinary case report
Mouse models of human cancer as tools in drug development.
- Journal:
- Cancer cell
- Year:
- 2004
- Authors:
- Holland, Eric C
- Affiliation:
- Memorial Sloan-Kettering Cancer Center · United States
Abstract
Histologically accurate mouse models of human cancers generated by somatic or germline genetic modification strategies recapitulate the genetic alterations found in human tumors. In this issue of Cancer Cell, test a novel signaling inhibitor in a genetically defined mouse medulloblastoma and show the utility of these models in drug development. They demonstrate that targeting signaling components downstream of tumor initiating mutations can be an effective therapeutic strategy for solid tumors.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15380508/